Dr Pedro Beltran-Alvarez

Lecturer in Biomedical Sciences

Faculty of Health Sciences

School of Life Sciences

p.beltran-alvarez@hull.ac.uk

01482 466624

Pedro did his PhD at the University of Bristol (2004-2007) funded by a Marie Curie grant from the EU.

After a short stage in the European Molecular Biology Laboratory (EMBL, Heildelberg, 2007-2009), he joined the Cardiovascular Research Centre at the University of Girona (2009), where he gained a Sara Borrell Postdoctoral Fellowship from the Spanish Government (2011-2014).

Pedro then joined the University of Hull in 2015 as a Lecturer. His laboratory has its own Facebook page featuring news and updates of his work.

Research

Research Interests

  • Post-translational modifications

  • Cardiovascular research

  • Cancer research

Research groups

My group is interested in how proteins' post-translational modifications change during cardiac disease, e.g. heart failure and atrial fibrillation. Within the 200 or so known post-translational modifications, we are particularly interested in arginine methylation, phosphorylation, and N-terminal acetylation.

We look at post-translational modifications both from a systems biology approach (proteome level), and from a reductionist approach (often using NaV1.5 as a model system). We use a range of biochemical and molecular biology techniques, often including mass spectrometry and proteomic approaches.

Publications

Onwuli D O, Yañez-Bisbe L, Pinsach-Abuin M L, Tarradas A, Brugada R, Greenman J, Pagans S, Beltran-Alvarez P, 'Do Sodium Channel Proteolytic Fragments Regulate Sodium Channel Expression?', Channels (Austin), 2017 Jul 18:1-6, doi: 10.1080/19336950.2017.1355663, [Epub ahead of print] PubMed PMID: 28718687.

Tarradas A, Pinsach-Abuin M L, Mackintosh C, Llorà-Batlle O, Pérez-Serra A, Batlle M, Pérez-Villa F, Zimmer T, Garcia-Bassets I, Brugada R, Beltran-Alvarez P, Pagans S, 'Transcriptional Regulation of the Sodium Channel Gene (SCN5A) by GATA4 in Human Heart', Journal of Molecular and Cellular Cardiology, 2017 Jan;102:74-82, doi: 10.1016/j.yjmcc.2016.10.013, Epub 2016 Nov 26, PubMed PMID: 27894866.

Onwuli D O, Rigau-Roca L, Cawthorne C, Beltran-Alvarez P, 'Mapping Arginine Methylation in the Human Body and Cardiac Disease', Proteomics Clinical Applications, 2017 Jan;11(1-2), doi: 10.1002/prca.201600106, Epub 2016 Nov 25, PubMed PMID: 27600370.

Beltran-Alvarez P, Feixas F, Osuna S, Díaz-Hernández R, Brugada R, Pagans S, 'Interplay between R513 Methylation and S516 Phosphorylation of the Cardiac Voltage-gated Sodium Channel', Amino Acids, 2015 Feb;47(2):429-34, doi: 10.1007/s00726-014-1890-0, Epub 2014 Dec 16, PubMed PMID: 25501501.

Full list

Teaching

Programmes taught on

Modules list

  • Biological Basis of Disease

  • Muscle Fitness and Failure

  • Clinical Biochemistry

  • Molecular Genetics and Proteomics

  • Diseases in Biomedicine

Research PhDs

Dr Beltran-Alvarez welcomes applications in post-translational modifications.

Current PhD supervisions 

  • Donatus O Onwuli

  • Sabrina Samuel

Professional highlights

Academic qualifications

  • Lecturership Biomedical Sciences, University of Hull

  • PhD University of Bristol