Chris Cawthorne

Dr Chris Cawthorne

Lecturer in Molecular Imaging

Faculty of Health Sciences

School of Life Sciences

c.cawthorne@hull.ac.uk

01482 465505

Dr Cawthorne is an experienced preclinical PET researcher, having worked in the field for over 10 years, with a background in cancer therapy and molecular pharmacology.

He is currently Lecturer in Molecular Imaging and Head of Preclinical Imaging in the PET Research Centre at the University of Hull.

Research

Research Interests

  • The application of Positron Emission Tomography (PET) to oncology

  • The validation of novel imaging probes for application as cancer biomarkers

  • The development of molecular radiotherapy tools

  • Preclinical PET quantitation

  • PET image reconstruction

Research groups

National Physical Laboratory/Xstrahl, development of small animal radiotherapy phantoms. http://www.npl.co.uk/science-technology/radiation-dosimetry/

Publications

Voulgari E, Bakandritsos A, Galtsidis S, Zoumpourlis V, Burke BP, Clemente GS, Cawthorne C, Archibald SJ, Tucek J, Zboril R, Kantarelou V, Karydas AG, Avgoustakis K. Synthesis, Characterisation and In Vivo Evaluation of a Magnetic Cisplatin Delivery Nanosystem based on PMAA-Graft-PEG Copolymers, Journal of Controlled Release 2016; Oct; 243:342-346 doi: 10.1016/j.jconrel.2016.10.021.

Heinzmann K, Honess DJ, Lewis DJ, Cawthorne C, Keen H, Heskamp S, Schelhaas S, Witney TH, Soloviev D, Williams KJ, Jacobs AH, Aboagye EO, Griffiths JR, Brindle KM, 'The Relationship Between Endogenous Thymidine Concentrations and [18F]FLT Uptake in a Range of Preclinical Tumour Models', European Journal of Nuclear Medicine and Molecular Imaging Research, 2016 6:63 DOI: 10.1186/s13550-016-0218-3

Nigam S, Burke BP, Davies,LH, Domarkas J, Wallis JF, Waddell PG, Waby JS, Benoit DM, Seymour AM, Cawthorne C, Higham LJ, Archibald SJ, 'Structurally Optimised BODIPY Derivatives for Imaging of Mitochondrial Dysfunction in Cancer and Heart Cells', Chemical Communications, 2016, 52, 7114 – 7117

Entract GM, Bryden F, Domarkas J, Savoie H, Allott L, Archibald SJ, Cawthorne C, Boyle RW, 'Development of PDT/PET Theranostics: Synthesis and Biological Evaluation of an 18F-Radiolabelled Water-Soluble Porphyrin', Molecular Pharmaceutics, 2015 Dec 7;12(12):4414-23

Cawthorne C, Burrows N, Gieling RG, Morrow CJ, Forster D, Gregory J, Radigois M, Smigova A, Babur M, Simpson K, Hodgkinson C, Brown G, McMahon A, Dive C, Hiscock D, Wilson I, Williams KJ, '[18F]-FLT Positron Emission Tomography can be used to Image the Response of Sensitive Tumours to PI3-Kinase Inhibition with the Novel Agent GDC-0941', Molecular Cancer Therapeutics, 2013 May; 12(5):819-28

Teaching

Programmes taught on

Modules list

  • Introduction to Cancer Imaging

  • Image Analysis

  • Imaging Modalities 1

  • Research Skills and Methods

  • Organ-specific Cancers-Bench to Bedside

  • Research Project and Dissertation

  • Treatment of Cancer

  • Cancer Biology

  • Research Project

Research PhDs

Completed PhDs 

Brocklesby K (2016), Development of a PET Radioligand Targeting Angiogenesis for Oncology Applications

Pacelli A (2015), Development of a PET Probe for the Imaging of COX-2 in Cancer

Allott L (2014), Development of Nuclear Receptor Imaging Agents

Teaching awards and accolades

  • Postgraduate Certificate in Academic Practice

  • Fellow of the Higher Education Academy

Professional highlights

Academic qualifications

  • BSc(Hons) Molecular Biology, University of Hertfordshire

  • PhD Molecular Pharmacology, University of Manchester